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QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications.

Authors
Type
Published Article
Journal
Chemical Communications
1364-548X
Publisher
The Royal Society of Chemistry
Publication Date
Volume
49
Issue
38
Pages
3985–3987
Identifiers
DOI: 10.1039/c3cc39104c
PMID: 23552819
Source
Medline
License
Unknown

Abstract

The fac-[(99m)Tc(OH2)3(CO)3](+) complex reacts with QD-filled micelles to create a bimodal SPECT-optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug.

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