Affordable Access

Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity.

Authors
  • P, Ralifo
  • L, Sanchez
  • Nc, Gassner
  • K, Tenney
  • Rs, Lokey
  • Tr, Holman
  • Fa, Valeriote
  • P, Crews
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Volume
70
Issue
1
Pages
95–99
Source
UCSC Cancer biomedical-ucsc
License
Unknown

Abstract

A re-collection of Plakortis quasiamphiaster from Vanuatu in 2003 resulted in the isolation of three known compounds, plakinidine A (1) and amphiasterins B1 (6) and B2 (7). Also isolated was a new bis-oxygenated pyrroloacridine alkaloid, plakinidine E (8), with a unique O-substitution versus N-substitution at position C-12 in 1. The biological evaluation of the active compounds in two assays provided complementary data. Plakinidine A (1) exhibited cytotoxicity against human colon H-116 cells with an IC50 of 0.23 microg/mL, but there were no effects against the yeast Saccharomyces cerevisiae diploid homozygous deletion strain of topoisomerase I (top1Delta). By contrast, 8 was inactive against H-116 cells but was potent in the yeast halo screen.

Report this publication

Statistics

Seen <100 times