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Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

Authors
  • Paruch, Kamil
  • Dwyer, Michael P
  • Alvarez, Carmen
  • Brown, Courtney
  • Chan, Tin-Yau
  • Doll, Ronald J
  • Keertikar, Kerry
  • Knutson, Chad
  • McKittrick, Brian
  • Rivera, Jocelyn
  • Rossman, Randall
  • Tucker, Greg
  • Fischmann, Thierry O
  • Hruza, Alan
  • Madison, Vincent
  • Nomeir, Amin A
  • Wang, Yaolin
  • Lees, Emma
  • Parry, David
  • Sgambellone, Nicole
  • And 12 more
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Nov 15, 2007
Volume
17
Issue
22
Pages
6220–6223
Identifiers
PMID: 17904841
Source
Medline
License
Unknown

Abstract

Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.

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