Affordable Access

p-Value Histograms: Inference and Diagnostics

Authors
  • breheny, patrick
  • stromberg, arnold
  • lambert, joshua
Publication Date
Aug 31, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

It is increasingly common for experiments in biology and medicine to involve large numbers of hypothesis tests. A natural graphical method for visualizing these tests is to construct a histogram from the p-values of these tests. In this article, we examine the shapes, both regular and irregular, that these histograms can take on, as well as present simple inferential procedures that help to interpret the shapes in terms of diagnosing potential problems with the experiment. We examine potential causes of these problems in detail, and discuss potential remedies. Throughout, examples of irregular-looking p-value histograms are provided and based on case studies involving real biological experiments.

Report this publication

Statistics

Seen <100 times