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Putative tissue markers in prostate cancer*.

Authors
  • Montironi, R
  • Cheng, L
  • Mazzucchelli, R
  • Santinelli, A
  • Bono, A
  • Lopez-Beltran, A
Type
Published Article
Journal
Urologia
Publication Date
Jan 01, 2008
Volume
75
Issue
3
Pages
149–155
Identifiers
PMID: 21086343
Source
Medline
License
Unknown

Abstract

A variety of putative prostate cancer markers have been described in human serum, urine, seminal fluid, and histological specimens. These markers exhibit varying capacities to detect prostate cancer and to predict disease course. In order to be considered markers for diagnosis or prognosis of disease course, and to be brought forward for large-scale clinical evaluation, they should fulfill several criteria. Firstly, there should be a biological or therapeutic rationale for choosing the marker, or at least a consistent association with disease presence, disease characteristics such as stage, or disease aggressiveness. Secondly, there should be an assessment of the strength of marker association with disease outcome. Thirdly, the marker should be assessed as an independent predictor in a multivariate analysis.

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