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Putative shared mechanisms in autism spectrum disorders and attention deficit hyperactivity disorder, a systematic review of the role of oxidative stress

Authors
  • Sa-Carneiro, Filipa1, 2, 3
  • Calhau, Conceição4, 5
  • Coelho, Rui1, 2
  • Figueiredo-Braga, Margarida1, 3, 6
  • 1 Faculty of Medicine of the University of Porto, Portugal , (Portugal)
  • 2 Centro Hospitalar São João, Porto , (Portugal)
  • 3 I3S-Instituto de Inovação e Investigação em Saúde, Porto , (Portugal)
  • 4 Center for Health Technology and Services Research (CINTESIS), Porto , (Portugal)
  • 5 Universidade Nova de Lisboa, Lisbon , (Portugal)
  • 6 University of Porto
Type
Published Article
Journal
Acta Neurobiologiae Experimentalis
Publisher
Exeley Inc.
Publication Date
Jan 01, 2020
Volume
80
Issue
2
Pages
129–138
Identifiers
DOI: 10.21307/ane-2020-013
Source
Exeley
Keywords
License
Green

Abstract

Oxidative stress is now believed to play a crucial role for neurodevelopment disorders such as autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD). To review the most recent literature regarding the role of oxidative stress for the pathophysiology of ASD and ADHD, we conducted a systematic search of the relevant literature and further discuss the clinical and research implications of this knowledge. A systematic search in PubMed database retrieved 132 articles, of which 33 were included in the review. This review found relevant evidence concerning the role of oxidative status in ASD and ADHD, albeit with some contradictory findings. In order to overcome the incongruities found, more studies are needed in the study of neurodevelopmental disorders, with more thorough study designs and particular attention to the accuracy of the diagnostic tools used for the cases included.

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