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Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure.

Authors
  • Scott, Adam C
  • Wensel, Roland
  • Davos, Constantinos H
  • Georgiadou, Panagiota
  • Ceri Davies, L
  • Coats, Andrew J S
  • Francis, Darrel P
  • Piepoli, Massimo F
Type
Published Article
Journal
European heart journal
Publication Date
Oct 01, 2004
Volume
25
Issue
20
Pages
1806–1813
Identifiers
PMID: 15474695
Source
Medline
License
Unknown

Abstract

In CHF, overactive muscle ergoreflex is associated with elevated blood concentration of PG and bradykinin. Modulation of these metabolite concentrations acutely reduces the muscle ergoreflex activity, which suggests a causative role in triggering and/or mediating the ergoreflex response.

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