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Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis.

Authors
  • Canepari, Marco1, 2, 3
  • 1 University of Grenoble Alpes, CNRS, LIPhy, F-38000, Grenoble, France. [email protected] , (France)
  • 2 Laboratories of Excellence, Ion Channel Science and Therapeutics, Valbonne, France. [email protected] , (France)
  • 3 Institut National de la Santé et Recherche Médicale, Paris, France. [email protected] , (France)
Type
Published Article
Journal
Cerebellum (London, England)
Publication Date
Dec 01, 2020
Volume
19
Issue
6
Pages
869–878
Identifiers
DOI: 10.1007/s12311-020-01164-0
PMID: 32654026
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Two recent studies have demonstrated that the dendritic Ca2+ signal associated with a climbing fibre (CF) input to the cerebellar Purkinje neuron (PN) depends on the membrane potential (Vm). Specifically, when the cell is hyperpolarised, this signal is mediated by T-type voltage-gated Ca2+ channels; in contrast, when the cell is firing, the CF-PN signal is mediated by P/Q-type voltage-gated Ca2+ channels. When the CF input is paired with parallel fibre (PF) activity, the signal is locally amplified at the sites of PF-activated synapses according to the Vm at the time of the CF input, suggesting that the standing Vm is a critical parameter for the induction of PF synaptic plasticity. In this review, I analyse how the Vm can potentially play a role in cerebellar learning focussing, in particular, on the hyperpolarised state that appears to occur episodically, since PNs are mostly firing under physiological conditions. By revisiting the recent literature reporting in vivo recordings and synaptic plasticity studies, I speculate on how a putative role of the PN Vm can provide an interpretation for the results of these studies.

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