Affordable Access

Access to the full text

Purkinje Cell Impairment Induced by Early Movement Restriction

Authors
  • Pascual, Rodrigo
  • Hervias, María C.
  • Tohá, María E.
  • Valero, Antoni
  • Figueroa, Héctor R.
Type
Published Article
Journal
Neonatology
Publisher
S. Karger AG
Publication Date
Dec 19, 1997
Volume
73
Issue
1
Pages
47–51
Identifiers
DOI: 10.1159/000013959
Source
Karger
Keywords
License
Green
External links

Abstract

In the present work the effects of movement restriction imposed during the early postweaning period on both Purkinje cell dendritic development and exploratory behavior were analyzed. Male and female Sprague-Dawley albino rats were reared either in isolated-restricted or social-standard environments from postnatal day 18 to 30. On the 31st postnatal day, all rats were behaviorally evaluated by the open-field test and then sacrificed under deep ether anesthesia. Vermian cerebellar sections were later stained with the Golgi-Cox-Sholl method and the Purkinje cell dendritic morphology was quantified under light microscopy. The results indicate that early somatomotor restriction severely impairs both exploratory behavior and Purkinje cell dendritic growth.

Report this publication

Statistics

Seen <100 times