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The purification of acid phosphatase from honey bee venom (Apis mellifica).

Authors
Type
Published Article
Journal
Toxicon
0041-0101
Publisher
Elsevier
Publication Date
Volume
25
Issue
10
Pages
1097–1103
Identifiers
PMID: 3424390
Source
Medline

Abstract

Acid phosphatase from bee venom was purified by a combination of saturated ammonium sulphate precipitation, gel filtration and ion exchange chromatography. The final product which is a glycoprotein contained less than 0.1% phospholipase A2 or hyaluronidase activity and existed in two molecular weight (96,000 and 45,000) forms. Acid phosphatase is a potent allergen, in bee venom allergic patients, which is capable of releasing histamine from sensitized human basophils and of inducing a wheal and flare reactions in sensitized human skin.

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