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Pure red cell aplasia and seronegative myasthenia gravis in association with thymoma.

Authors
  • Lee, Sun Yong1
  • Gill, Amandeep1
  • Jung, Syung Min1
  • 1 Internal Medicine, San Joaquin General Hospital (SJGH), French Camp, CA, USA.
Type
Published Article
Journal
Journal of Community Hospital Internal Medicine Perspectives
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jun 14, 2020
Volume
10
Issue
3
Pages
238–241
Identifiers
DOI: 10.1080/20009666.2020.1770019
PMID: 32864051
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Pure red cell aplasia is an uncommon paraneoplastic syndrome of thymoma. Myasthenia gravis is the most common paraneoplastic syndrome associated with thymoma. We present a case of a 79-year-old Pacific Islander female who presented with profound fatigue, generalized weakness, significant unintentional weight loss, bilateral ptosis, and anemia. The bone marrow biopsy showed near absence of erythroid elements consistent with pure red cell aplasia. Ice-pack test was consistent with myasthenia gravis and computed tomography of the chest demonstrated a thymoma. The patient was started on immunosuppressive treatment with prednisone and cyclosporine. This case demonstrates a rare combination of paraneoplastic manifestations of thymoma: pure red cell aplasia and myasthenia gravis. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

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