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Pulmonary complaints and lung function after pediatric kidney transplantation.

Authors
  • Cransberg, Karlien
  • Pijnenburg, Mariëlle
  • Lunstroot, Maaike
  • Lilien, Marc
  • Cornelissen, Elisabeth
  • Davin, Jean Claude
  • VanHoeck, Koen
  • Merkus, Peter
  • Nauta, Jeroen
Type
Published Article
Journal
Pediatric Transplantation
Publisher
Wiley (Blackwell Publishing)
Publication Date
Mar 01, 2008
Volume
12
Issue
2
Pages
201–206
Identifiers
DOI: 10.1111/j.1399-3046.2007.00810.x
PMID: 18307669
Source
Medline
License
Unknown

Abstract

Recently four of 38 children with a kidney transplant were diagnosed with bronchiectasis. The aim of the current study was to identify patients with increased risk for pulmonary damage. In this cross-sectional observational study, children with a functioning kidney graft in the Netherlands and Antwerp, Belgium, were screened with the use of a symptom checklist and spirometry. Maximum score for upper airway complaints was 21 (normal: <8), for lower airway complaints 28 (<10). Results of FVC, FEV(1) and MEF(25) were expressed as percentage predicted for height and sex. One hundred and thirty-five patients completed the interview (122) and/or spirometry (103); 91 did both. Lower airways symptoms were above acceptable levels in 18 (14%) patients. Forty-nine patients (48%) had an abnormal lung function test: in 12 concerning FVC%, in 11 FEV(1)%, in 24 MEF(25)% and in 36 FEV(1)/FVC. Of correlations between symptomatology or spirometry data, and clinical parameters, only that between GFR and MEF(25)% was statistically significant. Children with a kidney transplant are at increased risk for obstructive lung disease. We recommend to monitor lung function during the follow-up after renal transplantation.

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