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Pulmonary arterial hypertension reduces energy efficiency of right, but not left, rat ventricular trabeculae.

Authors
  • Pham, Toan1, 2
  • Nisbet, Linley1, 2
  • Taberner, Andrew1, 3
  • Loiselle, Denis1, 2
  • Han, June-Chiew1
  • 1 Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand. , (New Zealand)
  • 2 Department of Physiology, The University of Auckland, Auckland, New Zealand. , (New Zealand)
  • 3 Department of Engineering Science, The University of Auckland, Auckland, New Zealand. , (New Zealand)
Type
Published Article
Journal
The Journal of Physiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 01, 2018
Volume
596
Issue
7
Pages
1153–1166
Identifiers
DOI: 10.1113/JP275578
PMID: 29363144
Source
Medline
Keywords
License
Unknown

Abstract

Pulmonary arterial hypertension (PAH) greatly increases the afterload on the right ventricle (RV), triggering RV hypertrophy, which progressively leads to RV failure. In contrast, the disease reduces the passive filling pressure of the left ventricle (LV), resulting in LV atrophy. We investigated whether these distinct structural and functional consequences to the ventricles affect their respective energy efficiencies. We studied trabeculae isolated from both ventricles of Wistar rats with monocrotaline-induced PAH and their respective Control groups. Trabeculae were mounted in a calorimeter at 37°C. While contracting at 5 Hz, they were subjected to stress-length work-loops over a wide range of afterloads. They were subsequently required to undergo a series of isometric contractions at various muscle lengths. In both protocols, stress production, length change and suprabasal heat output were simultaneously measured. We found that RV trabeculae from PAH rats generated higher activation heat, but developed normal active stress. Their peak external work output was lower due to reduced extent and velocity of shortening. Despite lower peak work output, suprabasal enthalpy was unaffected, thereby rendering suprabasal efficiency lower. Crossbridge efficiency, however, was unaffected. In contrast, LV trabeculae from PAH rats maintained normal mechano-energetic performance. Pulmonary arterial hypertension reduces the suprabasal energy efficiency of hypertrophied right ventricular tissues as a consequence of the increased energy cost of Ca2+ cycling.

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