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PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo

Authors
  • Campbell, Jennie S.1, 2
  • Davidson, Andrew J.1
  • Todd, Henry1
  • Rodrigues, Frederico S.L.M.2
  • Elliot, Abigail M.1
  • Early, Jason J.3
  • Lyons, David A.3
  • Feng, Yi1
  • Wood, Will1
  • 1 Centre for Inflammation Research, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh EH16 4TJ, UK
  • 2 School of Cellular and Molecular Medicine, Faculty of Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK
  • 3 Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
Type
Published Article
Journal
Current Biology
Publisher
Cell Press
Publication Date
Feb 22, 2021
Volume
31
Issue
4
Pages
875–883
Identifiers
DOI: 10.1016/j.cub.2020.11.014
PMID: 33296680
PMCID: PMC7902905
Source
PubMed Central
Keywords
Disciplines
  • Report
License
Unknown

Abstract

Through the combination of proteomics, genetics, and live imaging, Campbell et al. identify Pez as a novel regulator of inflammation in vivo . Pez acts in the damage-sensing, H2O2/Src42a/Draper signaling axis, wherein it dynamically clusters with Draper to enable rapid leukocyte migration to epithelial wounds in both the fly and fish.

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