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PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Authors
  • Flosbach, Markus1
  • Oberle, Susanne G.2
  • Scherer, Stefanie1, 2
  • Zecha, Jana3
  • von Hoesslin, Madlaina1
  • Wiede, Florian4, 5
  • Chennupati, Vijaykumar2
  • Cullen, Jolie G.1
  • List, Markus6
  • Pauling, Josch K.7
  • Baumbach, Jan8
  • Kuster, Bernhard3
  • Tiganis, Tony4, 5, 9
  • Zehn, Dietmar1, 2
  • 1 Division of Animal Physiology and Immunology, TUM School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany
  • 2 Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
  • 3 Chair of Proteomics and Bioanalytics, TUM School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany
  • 4 Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
  • 5 Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia
  • 6 Big Data in BioMedicine Group, Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany
  • 7 ZD.B Junior Research Group LipiTUM, Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany
  • 8 Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany
  • 9 Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 28, 2020
Volume
32
Issue
4
Identifiers
DOI: 10.1016/j.celrep.2020.107957
PMID: 32726622
PMCID: PMC7408006
Source
PubMed Central
Keywords
License
Unknown

Abstract

Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.

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