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PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3.

Authors
  • Inazawa, J
  • Ariyama, T
  • Abe, T
  • Druck, T
  • Ohta, M
  • Huebner, K
  • Yanagisawa, J
  • Reed, J C
  • Sato, T
Type
Published Article
Journal
Genomics
Publication Date
Jan 15, 1996
Volume
31
Issue
2
Pages
240–242
Identifiers
PMID: 8824809
Source
Medline
License
Unknown

Abstract

PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila tumor suppressor protein, lethal-(1)-disc-large-1 (dlg-1). The localization of the PTPN13 gene to human chromosome 4q21.3 was determined by both FISH and PCR analysis of somatic cell hybrids. This 4q21.3 chromosomal region contains a gene for autosomal dominant polycystic kidney disease as well as the region frequently deleted in liver and ovarian cancers, suggesting that PTPN13 is a candidate for one of the putative tumor suppressor genes on the long arm of chromosome 4.

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