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PTEN inhibitor improves vascular remodeling and cardiac function after myocardial infarction through PI3k/Akt/VEGF signaling pathway

Authors
  • Feng, Qiuting1
  • Li, Xing1
  • Qin, Xian1
  • Yu, Cheng1
  • Jin, Yan1
  • Qian, Xiaojun1
  • 1 the Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, No.68, Zhongshan Road, Wuxi, Jiangsu, 214002, China , Wuxi (China)
Type
Published Article
Journal
Molecular Medicine
Publisher
BioMed Central
Publication Date
Nov 19, 2020
Volume
26
Issue
1
Identifiers
DOI: 10.1186/s10020-020-00241-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundMyocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, the efficacy for MI treatment remains unsatisfactory. Therefore, it is urgent to develop a novel therapeutic strategy.MethodsLeft anterior descending arteries (LAD) of mice were ligated to induce MI. Another set of mice were intravenously injected with PTEN inhibitor BPV (1 mg/kg) 1 h after LAD ligation and continued to receive BPV injection daily for the following 6 days. Mice were performed echocardiography 14 days after surgery.ResultsMice in MI group displayed an increased expression of PTEN with impaired cardiac function, enhanced cardiomyocyte apoptosis and decreased angiogenesis. BPV treatment significantly improved cardiac function, with reduced cardiomyocyte apoptosis, promoted angiogenesis, and activated PI3K/Akt/vascular endothelial growth factor (VEGF) signaling pathway.ConclusionPTEN inhibitor BPV could effectively prevent myocardial infarction in mice, highlighting its potential as a candidate therapeutic drug.

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