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PTEN Gene Induces Cell Invasion and Migration via Regulating AKT/GSK-3β/β-Catenin Signaling Pathway in Human Gastric Cancer.

Authors
  • Ma, Jingjing1, 2, 3
  • Guo, Xufeng4, 2
  • Zhang, Jixiang1, 2, 3
  • Wu, Dandan1
  • Hu, Xue1
  • Li, Jiao1
  • Lan, Qingzhi1
  • Liu, Ya1
  • Dong, Weiguo5
  • 1 Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhang Zhi-dong Road, Wuhan, 430060, Hubei Province, People's Republic of China. , (China)
  • 2 Key Laboratory of Hubei Province for Digestive System Disease, Wuhan, Hubei Province, People's Republic of China. , (China)
  • 3 Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China. , (China)
  • 4 Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China. , (China)
  • 5 Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 99 Zhang Zhi-dong Road, Wuhan, 430060, Hubei Province, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Dec 01, 2017
Volume
62
Issue
12
Pages
3415–3425
Identifiers
DOI: 10.1007/s10620-017-4764-y
PMID: 29030742
Source
Medline
Keywords
License
Unknown

Abstract

Our results indicated PTEN gene might induce cell invasion and migration via regulating AKT/GSK-3β/β-catenin signaling pathway, playing a vital role in the progression of gastric cancer.

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