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Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome

Authors
  • Evans, Elizabeth A.1
  • Sayers, Sophie R.1
  • Kodji, Xenia2, 3
  • Xia, Yue1
  • Shaikh, Mahum1
  • Rizvi, Alizah1
  • Frame, James4, 5
  • Brain, Susan D.2
  • Philpott, Michael P.6
  • Hannen, Rosalind F.6
  • Caton, Paul W.1
  • 1 Department of Diabetes, School of Life Course Sciences, King's College London, UK
  • 2 Section of Vascular Biology & Inflammation, School of Cardiovascular Medicine & Sciences, BHF Centre for Cardiovascular Sciences, King's College London, London, UK
  • 3 A∗STAR - Agency for Science, Technology and Research - SRIS, Singapore
  • 4 Anglia-Ruskin University, Chelmsford, Essex, UK
  • 5 Springfield Hospital, Chelmsford, UK
  • 6 Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jun 26, 2020
Volume
41
Identifiers
DOI: 10.1016/j.molmet.2020.101047
PMID: 32599074
PMCID: PMC7452265
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Topical IMQ treatment induced a psoriatic-like phenotype in mouse skin. • Skin IMQ treatment induced inflammation and signs of metabolic dysfunction in sub-cutaneous and epidydimal adipose tissue, liver, skeletal muscle and gut tissue. • Skin IMQ treatment induced islet compensation characterised by increased insulin and c-peptide response to glucose, and increased beta cell proliferation. • The in vivo IMQ mouse phenotype is partially replicated by exposure of sAT and pancreatic islets to psoriatic-skin conditioned media. • Psoriatic skin inflammation, potentially through the endocrine actions of the skin secretome, may constitute a novel pathophysiological pathway mediating the development of T2D.

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