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Pseudokinases: a tribble-edged sword.

Authors
  • Richmond, Laura1
  • Keeshan, Karen1
  • 1 Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, UK.
Type
Published Article
Journal
FEBS Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2020
Volume
287
Issue
19
Pages
4170–4182
Identifiers
DOI: 10.1111/febs.15096
PMID: 31621188
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis, prognosis, prediction and clinical strategy. In their role as signalling mediators and scaffolding proteins, TRIBs lead to changes in protein stability and activity, which impact on diverse cellular processes such as proliferation, differentiation, cell cycle and cell death. We review the role of TRIB proteins as promising therapeutic targets, with an emphasis on their role in cancer, and as biomarkers, with potential application across diverse pathological processes. © 2019 Federation of European Biochemical Societies.

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