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Pseudohexagonal 2D DNA crystals from double crossover cohesion.

Authors
  • Ding, Baoquan
  • Sha, Ruojie
  • Seeman, Nadrian C
Type
Published Article
Journal
Journal of the American Chemical Society
Publication Date
Aug 25, 2004
Volume
126
Issue
33
Pages
10230–10231
Identifiers
PMID: 15315420
Source
Medline
License
Unknown

Abstract

Two-dimensional pseudohexagonal trigonal arrays have been constructed by self-assembly from DNA. The motif used is a bulged-junction DNA triangle whose edges and extensions are DNA double crossover (DX) molecules, rather than conventional DNA double helices. Experiments were performed to establish whether the success of this system results from the added stiffness of DX molecules or the presence of two sticky ends at the terminus of each edge. Removal of one sticky end precludes lattice formation, suggesting that it is the double sticky end that is the primary factor enabling lattice formation.

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