Affordable Access

deepdyve-link
Publisher Website

PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract.

Authors
  • Dembek, Till A1
  • Petry-Schmelzer, Jan Niklas2
  • Reker, Paul2
  • Wirths, Jochen3
  • Hamacher, Stefanie4
  • Steffen, Julia2
  • Dafsari, Haidar S2
  • Hövels, Mauritius3
  • Fink, Gereon R5
  • Visser-Vandewalle, Veerle3
  • Barbe, Michael T2
  • 1 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Germany. Electronic address: [email protected] , (Germany)
  • 2 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Germany. , (Germany)
  • 3 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotactic and Functional Neurosurgery, Germany. , (Germany)
  • 4 University of Cologne, Institute of Medical Statistics and Computational Biology, Germany. , (Germany)
  • 5 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany. , (Germany)
Type
Published Article
Journal
NeuroImage Clinical
Publisher
Elsevier
Publication Date
Jan 01, 2020
Volume
26
Pages
102235–102235
Identifiers
DOI: 10.1016/j.nicl.2020.102235
PMID: 32172171
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate the relation between deep brain stimulation (DBS) of the posterior-subthalamic-area (PSA) and the ventral-intermediate-nucleus (VIM) and the distance to the dentatorubrothalamic tract (DRTT) in essential tremor (ET). Tremor rating scale (TRS) hemi-scores were analyzed in 13 ET patients, stimulated in both the VIM and the PSA in a randomized, crossover trial. Distances of PSA and VIM contacts to population-based DRTTs were calculated. The relationships between distance to DRTT and stimulation amplitude, as well as DBS efficiency (TRS improvement per amplitude) were investigated. PSA contacts were closer to the DRTT (p = 0.019) and led to a greater improvement in TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to the DRTT was related to lower amplitudes (p < 0.001) and higher DBS efficiency (p = 0.017). Differences in tremor outcome and stimulation parameters between contacts in the PSA and the VIM can be explained by their different distance to the DRTT. Copyright © 2020. Published by Elsevier Inc.

Report this publication

Statistics

Seen <100 times