Affordable Access

Access to the full text

PS14 - 73. Effect of fasting on energy- and nutrient-sensing pathways in human skeletal muscle

Authors
  • Wijngaarden, Marjolein A.1
  • Bakker, Leontine E.H.2
  • van Dijk, Ko Willems3
  • Jazet, Ingrid2
  • Pijl, Hanno1
  • Guigas, Bruno4
  • 1 Leiden University Medical Center, Department of Endocrinology and Metabolism, Leiden, The Netherlands , Leiden (Netherlands)
  • 2 Leiden University Medical Center, Department of General Internal Medicine, Leiden, The Netherlands , Leiden (Netherlands)
  • 3 Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands , Leiden (Netherlands)
  • 4 Leiden University Medical Center, Department of Molecular Cell Biology, Leiden, The Netherlands , Leiden (Netherlands)
Type
Published Article
Journal
Nederlands Tijdschrift voor Diabetologie
Publisher
Bohn Stafleu van Loghum
Publication Date
Nov 01, 2011
Volume
9
Issue
3
Pages
140–140
Identifiers
DOI: 10.1007/s12467-011-0098-0
Source
Springer Nature
Keywords
License
Yellow

Abstract

During fasting, rapid metabolic adaptations, such as a shift from carbohydrate to lipid oxidation, are required to maintain whole-body energy homeostasis. This mainly occurs by tissue-specific coordinated regulation of several nutrient and energy-sensitive pathways. Animal studies suggest that activation of the AMP-activated kinase (AMPK) triggers transcriptional modulation of genes involved in lipid and glucose metabolism. Sirtuin-1 (SIRT1) and histone deacetylase 4 (HDAC4) were recently proposed to play a central role in this AMPK-mediated transcriptional regulation of energy metabolism. Our aim is therefore to investigate the effects of fasting on AMPK/SIRT1/HDAC4 signaling pathways in human skeletal muscle.

Report this publication

Statistics

Seen <100 times