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Prussian Blue/Calcium Peroxide Nanocomposites-Mediated Tumor Cell Iron Mineralization for Treatment of Experimental Lung Adenocarcinoma.

Authors
  • Zhang, Kaixin1
  • Wu, Jicheng1
  • Zhao, Xiaoxiong1
  • Qin, Jiale
  • Xue, Yi1
  • Zheng, Weizeng
  • Wang, Lixiu
  • Wang, Haoran1
  • Shen, Hong
  • Niu, Tianye2
  • Luo, Yan3
  • Tang, Ruikang4
  • Wang, Ben1
  • 1 Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China. , (China)
  • 2 Nuclear & Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States. , (Georgia)
  • 3 Department of Biochemistry, Zhejiang University School of Medicine, Hangzhou 310058, China. , (China)
  • 4 Department of Chemistry, Zhejiang University, Hangzhou 310027, China. , (China)
Type
Published Article
Journal
ACS Nano
Publisher
American Chemical Society
Publication Date
Dec 01, 2021
Identifiers
DOI: 10.1021/acsnano.1c07308
PMID: 34851083
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Current lung cancer diagnosis methods encounter delayed visual confirmation of tumor foci and low-resolution metrics in imaging findings, which delays the early treatment of tumors. Here, we developed a potent lung cancer imaging and treatment strategy centered around a nanotransformational concept of tumor iron mineralization in situ, which employs Prussian blue/calcium peroxide nanocomposites as a precursor. The resultant iron mineralization in tumor cells greatly facilitates the early and differential diagnosis of lung carcinoma from benign nodules via medical imaging, meanwhile introducing oxidative stress to activate the cellular apoptosis and ferroptosis pathways, resulting in inhibition of the malignant behavior of tumor cells. Tumor-microenvironment-triggered iron mineralization enables integration of the detection and prevention of tumor metastasis at its early stages with no assistance of toxic drugs, which offers a potential solution for the precise management of lung cancer with ideal outcomes.

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