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Protozoa traversal of the blood-brain barrier to invade the central nervous system.

Authors
  • Elsheikha, Hany M
  • Khan, Naveed Ahmed
Type
Published Article
Journal
FEMS Microbiology Reviews
Publisher
Oxford University Press
Publication Date
Jul 01, 2010
Volume
34
Issue
4
Pages
532–553
Identifiers
DOI: 10.1111/j.1574-6976.2010.00215.x
PMID: 20337721
Source
Medline
License
Unknown

Abstract

Neuropathogenic protozoa have evolved strategies to breach the blood-brain barrier and invade the central nervous system. These include transcellular, paracellular and the Trojan horse routes but the associated molecular mechanisms remain incompletely understood. Here, we summarize the current understanding of protozoa penetration across the blood-brain barrier, focusing on Plasmodium, Babesia, Trypanosoma, Toxoplasma, Acanthamoeba and Balamuthia. Advances in understanding the molecular pathways will offer opportunities for the rational development of novel therapeutic interventions.

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