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Proton MRS in Kennedy disease: absolute metabolite and macromolecular concentrations.

Authors
  • Mader, Irina
  • Karitzky, Jochen
  • Klose, Uwe
  • Seeger, Uwe
  • Sperfeld, Anne
  • Naegele, Thomas
  • Schick, Fritz
  • Ludolph, Albert
  • Grodd, Wolfgang
Type
Published Article
Journal
Journal of magnetic resonance imaging : JMRI
Publication Date
Aug 01, 2002
Volume
16
Issue
2
Pages
160–167
Identifiers
PMID: 12203763
Source
Medline
License
Unknown

Abstract

The elevated MM at 0.9 ppm may be attributed to a pathologically altered protein in KD. Additionally, the changes of Ins point to a clinically unexpected involvement of the motor cortex. The correlation of NAA/Cr with the number of CAG repeats indicates a link between metabolites and genetic failure.

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