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Proteotoxicity and Neurodegenerative Diseases

Authors
  • Ruz, Clara1
  • Alcantud, Jose Luis1
  • Vives Montero, Francisco1
  • Duran, Raquel1
  • Bandres-Ciga, Sara2
  • 1 (R.D.)
  • 2 Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Aug 06, 2020
Volume
21
Issue
16
Identifiers
DOI: 10.3390/ijms21165646
PMID: 32781742
PMCID: PMC7460676
Source
PubMed Central
Keywords
License
Green

Abstract

Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among these incurable and debilitating conditions. Cell proteome alteration is considered to be one of the main driving forces that triggers neurodegeneration, and unraveling the biological complexity behind the affected molecular pathways constitutes a daunting challenge. This review summarizes the current state on key processes that lead to cellular proteotoxicity in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis, providing a comprehensive landscape of recent literature. A foundational understanding of how proteotoxicity affects disease etiology and progression may provide essential insight towards potential targets amenable of therapeutic intervention.

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