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The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19 CCAN Complex in Meiotic Kinetochore Assembly

Authors
  • Borek, Weronika E.1
  • Vincenten, Nadine1
  • Duro, Eris1
  • Makrantoni, Vasso1
  • Spanos, Christos1
  • Sarangapani, Krishna K.2
  • de Lima Alves, Flavia1
  • Kelly, David A.1
  • Asbury, Charles L.2
  • Rappsilber, Juri1, 3
  • Marston, Adele L.1
  • 1 The Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK
  • 2 Department of Physiology & Biophysics, University of Washington, Seattle, WA 98195-7290, USA
  • 3 Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355 Berlin, Germany
Type
Published Article
Journal
Current Biology
Publisher
Cell Press
Publication Date
Jan 25, 2021
Volume
31
Issue
2
Pages
283–296
Identifiers
DOI: 10.1016/j.cub.2020.10.025
PMID: 33157029
PMCID: PMC7846277
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Kinetochores need to be specialized to direct the distinctive pattern of chromosome segregation in meiosis. Borek et al. reveal the protein composition of kinetochores in meiosis and identify a critical assembly pathway that promotes meiotic kinetochore specialization.

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