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Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases.

Authors
  • Aibara, Nozomi1
  • Ichinose, Kunihiro2
  • Baba, Miyako1
  • Nakajima, Hideki3
  • Satoh, Katsuya4
  • Atarashi, Ryuichiro5
  • Kishikawa, Naoya1
  • Nishida, Noriyuki6
  • Kawakami, Atsushi2
  • Kuroda, Naotaka1
  • Ohyama, Kaname7
  • 1 Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. , (Japan)
  • 2 Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. , (Japan)
  • 3 Department of Clinical Neuroscience and Neurology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. , (Japan)
  • 4 Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. , (Japan)
  • 5 Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. , (Japan)
  • 6 Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. , (Japan)
  • 7 Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Electronic address: [email protected] , (Japan)
Type
Published Article
Journal
Clinica chimica acta; international journal of clinical chemistry
Publication Date
May 18, 2018
Volume
484
Pages
26–31
Identifiers
DOI: 10.1016/j.cca.2018.05.026
PMID: 29775619
Source
Medline
Keywords
License
Unknown

Abstract

This report is the first to comprehensively identify the antigens incorporated into ICs in CSF. There was limited overlap between the antigens we identified and the CSF proteome or the plasma proteome; therefore, our method can be distinguished from the conventional CSF proteome analysis. Although the sensitivity of disease-specific IC-antigens detected in immune complexome analysis screening, the sensitivity may be improved by developing an ELISA method specifically for detecting the ICs. Immune complexome analysis of CSF may be a new and promising path to biomarker discovery for diagnosis and study for CNS autoimmune diseases.

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