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Proteome analysis of human arterial tissue discloses associations between the vascular content of small leucine-rich repeat proteoglycans and pulse wave velocity.

Authors
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
1524-4636
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
35
Issue
8
Pages
1896–1903
Identifiers
DOI: 10.1161/ATVBAHA.114.304706
PMID: 26069235
Source
Medline
Keywords
  • Extracellular Matrix Proteins
  • Proteoglycans
  • Proteomics
  • Pulse Wave Analysis
  • Vascular Smooth Muscle Cells
  • Vascular Stiffness

Abstract

Changes in the arterial amounts of small leucine-rich proteoglycans, known to be involved in collagen fibrillogenesis, and of some nonfibrillar collagens in combination with alterations in proteins related to functions of the human arterial smooth muscle are associated with arterial stiffness, as determined by PWV.

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