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Proteolysis: anytime, any place, anywhere?

Authors
  • Pines, Jonathon
  • Lindon, Catherine
Type
Published Article
Journal
Nature cell biology
Publication Date
Aug 01, 2005
Volume
7
Issue
8
Pages
731–735
Identifiers
PMID: 16056263
Source
Medline
License
Unknown

Abstract

Proteolysis via the ubiquitin-proteasome system (UPS) is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. However, an added dimension to the control of protein degradation is possible because the ubiquitin system can be spatially regulated. Controlling where a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments even in the mitotic cell. Here, we discuss this aspect of the UPS.

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