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Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Authors
  • Chen, Jiawen
  • Sun, Tianyu
  • You, Yan
  • Wu, Buling
  • Wang, Xiaofang
  • Wu, Jingyi
Type
Published Article
Journal
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Publication Date
Nov 30, 2021
Volume
9
Identifiers
DOI: 10.3389/fcell.2021.760532
Source
Frontiers
Keywords
Disciplines
  • Cell and Developmental Biology
  • Review
License
Green

Abstract

Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.

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