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Protein-spatiotemporal partition releasing gradient porous scaffolds and anti-inflammatory and antioxidant regulation remodel tissue engineered anisotropic meniscus.

Authors
  • Xu, Bingbing1, 2
  • Ye, Jing1, 2
  • Fan, Bao-Shi1, 2
  • Wang, Xinjie1, 2
  • Zhang, Ji-Ying1, 2
  • Song, Shitang1, 2
  • Song, Yifan1, 2
  • Jiang, Wen-Bo3
  • Wang, Xing4, 5
  • Yu, Jia-Kuo1, 2
  • 1 Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No.49, North Garden Road, Haidian District, Beijing 100191, PR China. , (China)
  • 2 Peking University Institute of Sports Medicine, No.49, North Garden Road, Haidian District, Beijing 100191, PR China. , (China)
  • 3 Clinical Translational R&D Center of 3D Printing Technology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, PR China. , (China)
  • 4 Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China. , (China)
  • 5 University of Chinese Academy of Sciences, Beijing, 100049, PR China. , (China)
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Feb 01, 2023
Volume
20
Pages
194–207
Identifiers
DOI: 10.1016/j.bioactmat.2022.05.019
PMID: 35702607
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Meniscus is a wedge-shaped fibrocartilaginous tissue, playing important roles in maintaining joint stability and function. Meniscus injuries are difficult to heal and frequently progress into structural breakdown, which then leads to osteoarthritis. Regeneration of heterogeneous tissue engineering meniscus (TEM) continues to be a scientific and translational challenge. The morphology, tissue architecture, mechanical strength, and functional applications of the cultivated TEMs have not been able to meet clinical needs, which may due to the negligent attention on the importance of microenvironment in vitro and in vivo. Herein, we combined the 3D (three-dimensional)-printed gradient porous scaffolds, spatiotemporal partition release of growth factors, and anti-inflammatory and anti-oxidant microenvironment regulation of Ac2-26 peptide to prepare a versatile meniscus composite scaffold with heterogeneous bionic structures, excellent biomechanical properties and anti-inflammatory and anti-oxidant effects. By observing the results of cell activity and differentiation, and biomechanics under anti-inflammatory and anti-oxidant microenvironments in vitro, we explored the effects of anti-inflammatory and anti-oxidant microenvironments on construction of regional and functional heterogeneous TEM via the growth process regulation, with a view to cultivating a high-quality of TEM from bench to bedside. © 2022 The Authors.

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