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Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation

Authors
  • Schneider, Kim1
  • Nelson, Geoffrey Michael1
  • Watson, Joseph Luke1
  • Morf, Jörg2
  • Dalglish, Maximillian1
  • Luh, Laura Martina1
  • Weber, Annika1
  • Bertolotti, Anne1
  • 1 MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom
  • 2 Wellcome - MRC Cambridge Stem Cell Institute, Puddicombe Way, Cambridge CB2 0AW, United Kingdom
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Sep 15, 2020
Volume
32
Issue
11
Identifiers
DOI: 10.1016/j.celrep.2020.108154
PMID: 32937139
PMCID: PMC7495045
Source
PubMed Central
Keywords
License
Unknown

Abstract

Here, we find that translation attenuation following eIF2α phosphorylation is not uniform, with long-lived proteins, including cytosolic and mitochondrial ribosomal subunits, being prominently downregulated. Because protein stability buffers the cost of translational attenuation, there is no measurable decrease of the targeted proteins. This reveals an evolutionary principle of cellular robustness.

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