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Protein oxidation and lens opacity in humans.

Authors
  • Boscia, F
  • Grattagliano, I
  • Vendemiale, G
  • Micelli-Ferrari, T
  • Altomare, E
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Aug 01, 2000
Volume
41
Issue
9
Pages
2461–2465
Identifiers
PMID: 10937554
Source
Medline
License
Unknown

Abstract

Idiopathic senile, diabetic, and myopic cataractogenesis appear to be dependent on oxidative damage to lens proteins. This damage occurs earlier in myopic and diabetic patients. Values of P-SH below and protein carbonyls above their specific threshold were found to be predictive for the presence of cataract. Because increased oxidation was observed in clear lenses removed from myopic and diabetic subjects, oxidation may be involved in the pathogenesis of these forms of human cataract.

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