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Protein kinase C stimulation enhances the process formation of adult oligodendrocytes and induces proliferation.

Authors
Type
Published Article
Journal
Journal of Neuroscience Research
0360-4012
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
29
Issue
4
Pages
481–489
Identifiers
PMID: 1791639
Source
Medline

Abstract

Oligodendrocytes (OL) isolated from adult pig brains regenerate their processes and form a network of fibers after 14-18 days in vitro (DIV). Stimulation of protein kinase C (Pk-C) by tumour promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) produces at day 7 in vitro a similar network after only 20 hr. H-7, an inhibitor of Pk-C, as well as amiloride, which inhibits the subsequent Na+/H+ exchange, reversibly suppress this effect. Activation of the protein kinase A or calmodulin pathway do not result in an increased OL process production. Furthermore, TPA induced proliferation in a subpopulation of OL. We conclude that the stimulation of Pk-C is of utmost importance for OL regeneration.

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