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Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1

Authors
  • De Luca, Elisa1, 2, 3
  • Perrelli, Andrea1, 2
  • Swamy, Harsha4
  • Nitti, Mariapaola5
  • Passalacqua, Mario5
  • Furfaro, Anna Lisa5
  • Salzano, Anna Maria6
  • Scaloni, Andrea6
  • Glading, Angela J.4
  • Retta, Saverio Francesco1, 2
  • 1 University of Torino, Department of Clinical and Biological Sciences, 10043 Orbassano, Torino , (Italy)
  • 2 University of Torino, CCM Italia Research Network, National Coordination Center at the Department of Clinical and Biological Sciences, 10043 Orbassano, Torino , (Italy)
  • 3 Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, 73010 Arnesano, Lecce , (Italy)
  • 4 University of Rochester, Department of Pharmacology and Physiology, Rochester, NY 14642
  • 5 University of Genoa, Department of Experimental Medicine, 16132 Genova , (Italy)
  • 6 ISPAAM, National Research Council, Proteomics & Mass Spectrometry Laboratory, 80147 Napoli , (Italy)
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Feb 04, 2021
Volume
134
Issue
3
Identifiers
DOI: 10.1242/jcs.250217
PMID: 33443102
PMCID: PMC7875496
Source
PubMed Central
Keywords
License
Green

Abstract

Summary: A novel role for PKC signaling in triggering Ser/Thr phosphorylation and regulating nucleocytoplasmic shuttling of KRIT1, a major protein with pleiotropic functions associated with human diseases.

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