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Protein folding: versatility of the cytosolic chaperonin TRiC/CCT.

Authors
  • Leroux, M R
  • Hartl, F U
Type
Published Article
Journal
Current Biology
Publisher
Elsevier
Publication Date
Apr 06, 2000
Volume
10
Issue
7
Identifiers
PMID: 10753735
Source
Medline
License
Unknown

Abstract

Efficient de novo folding of actins and tubulins requires two molecular chaperones, the chaperonin TRiC (or CCT) and its novel cofactor GimC (or prefoldin). Recent studies indicate that TRiC is exquisitely adapted for this task, yet has the ability to interact with and assist the folding of numerous other cellular proteins.

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