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Protein-expression profiles in mouse blood-plasma following acute whole-body exposure to (137)Cs gamma rays.

Authors
  • Rithidech, Kanokporn Noy
  • Honikel, Louise
  • Rieger, Robert
  • Xie, Weiping
  • Fischer, Thomas
  • Simon, Sanford R
Type
Published Article
Journal
International journal of radiation biology
Publication Date
May 01, 2009
Volume
85
Issue
5
Pages
432–447
Identifiers
DOI: 10.1080/09553000902820390
PMID: 19365744
Source
Medline
License
Unknown

Abstract

Although different proteins (mostly involved in inflammatory responses) were detected in exposed-mice, alterations in expression-levels of clusterin, gelsolin, kininogen, and alpha-2-HS-glycoproteins were found at both times. Despite the need for validation, the results suggested that alterations in expression-levels of specific proteins may be indicative of radiation-exposure. The results also provided the important step in an eventual establishment of blood-based biomarkers of radiation-exposure in vivo.

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