Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases

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Protein disulfide isomerase as a prosurvival factor in cell therapy for muscular and vascular diseases

Authors
  • Di Rocco, Giuliana
  • Baldari, Silvia
  • Gentile, Antonietta
  • Capogrossi, Maurizio
  • Toietta, Gabriele
Type
Published Article
Journal
Stem Cell Research & Therapy
Publisher
Springer Nature America, Inc
Publication Date
Sep 25, 2018
Volume
9
Issue
1
Identifiers
DOI: 10.1186/s13287-018-0986-y
PMID: 30257707
Source
MyScienceWork
Keywords
License
Green

Abstract

Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endoplasmic reticulum (ER) is an organelle involved in protein folding, calcium homeostasis, and lipid biosynthesis. Protein disulfide isomerase (PDI) is a molecular chaperone induced and activated by ER stress. PDI is induced by hypoxia in neuronal, cardiac, and endothelial cells, supporting increased cell survival to hypoxic stress and protection from apoptosis in response to ischemia.

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