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Protein crystal growth in microgravity using a liquid/liquid diffusion method.

Authors
Type
Published Article
Journal
Microgravity science and technology
Publication Date
Volume
9
Issue
4
Pages
281–283
Identifiers
PMID: 11540170
Source
Medline

Abstract

Crystallization of proteins by liquid liquid diffusion method was performed in microgravity using the MDA Minilab aboard the US Space Shuttle. Three proteins, namely lysozyme, trichosanthin, and a new lechin, were crystallized in the space experiment. In contrast to the results of space experiments with a tube-like vapor diffusion method, the crystallization conditions for growing better crystals in space are remarkably different from the conditions optimized on earth. This may be due to difficulties in ground optimization, which are caused by gravity-dependent phenomena, in particular the specific convective flow occurring with liquid liquid diffusion.

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