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Protective ventilation and outcomes of critically ill patients with COVID-19: a cohort study

  • Ferreira, Juliana C.1, 2
  • Ho, Yeh-Li3
  • Besen, Bruno Adler Maccagnan Pinheiro4
  • Malbouisson, Luiz Marcelo Sa5
  • Taniguchi, Leandro Utino4
  • Mendes, Pedro Vitale4
  • Costa, Eduardo Leite Vieira1
  • Park, Marcelo4
  • Daltro-Oliveira, Renato2, 3
  • Roepke, Roberta M. L.2, 5
  • Silva-Jr, Joao M.5
  • Carmona, Maria Jose Carvalho5
  • Carvalho, Carlos R. R.1
  • Hirota, Adriana
  • Kanasiro, Alberto Kendy
  • Crescenzi, Alessandra
  • Fernandes, Amanda Coelho
  • Miethke-Morais, Anna
  • Bellintani, Arthur Petrillo
  • Canasiro, Artur Ribeiro
  • And 71 more
  • 1 Universidade de Sao Paulo, São Paulo, Brazil , São Paulo (Brazil)
  • 2 AC Camargo Cancer Center, São Paulo, Brazil , São Paulo (Brazil)
  • 3 Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil , Sao Paulo (Brazil)
  • 4 Universidade de São Paulo, São Paulo, SP, Brazil , São Paulo (Brazil)
  • 5 Universidade de Sao Paulo, Sao Paulo, SP, Brazil , Sao Paulo (Brazil)
Published Article
Annals of Intensive Care
Springer (Biomed Central Ltd.)
Publication Date
Jun 07, 2021
DOI: 10.1186/s13613-021-00882-w
Springer Nature


BackgroundApproximately 5% of COVID-19 patients develop respiratory failure and need ventilatory support, yet little is known about the impact of mechanical ventilation strategy in COVID-19. Our objective was to describe baseline characteristics, ventilatory parameters, and outcomes of critically ill patients in the largest referral center for COVID-19 in Sao Paulo, Brazil, during the first surge of the pandemic.MethodsThis cohort included COVID-19 patients admitted to the intensive care units (ICUs) of an academic hospital with 94 ICU beds, a number expanded to 300 during the pandemic as part of a state preparedness plan. Data included demographics, advanced life support therapies, and ventilator parameters. The main outcome was 28-day survival. We used a multivariate Cox model to test the association between protective ventilation and survival, adjusting for PF ratio, pH, compliance, and PEEP.ResultsWe included 1503 patients from March 30 to June 30, 2020. The mean age was 60 ± 15 years, and 59% were male. During 28-day follow-up, 1180 (79%) patients needed invasive ventilation and 666 (44%) died. For the 984 patients who were receiving mechanical ventilation in the first 24 h of ICU stay, mean tidal volume was 6.5 ± 1.3 mL/kg of ideal body weight, plateau pressure was 24 ± 5 cmH2O, respiratory system compliance was 31.9 (24.4–40.9) mL/cmH2O, and 82% of patients were ventilated with protective ventilation. Noninvasive ventilation was used in 21% of patients, and prone, in 36%. Compliance was associated with survival and did not show a bimodal pattern that would support the presence of two phenotypes. In the multivariable model, protective ventilation (aHR 0.73 [95%CI 0.57–0.94]), adjusted for PF ratio, compliance, PEEP, and arterial pH, was independently associated with survival.ConclusionsDuring the peak of the epidemic in Sao Paulo, critically ill patients with COVID-19 often required mechanical ventilation and mortality was high. Our findings revealed an association between mechanical ventilation strategy and mortality, highlighting the importance of protective ventilation for patients with COVID-19.

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