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Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells.

Authors
  • Jung, Keunok
  • Kang, Miseon
  • Park, Cheol
  • Hyun Choi, Yung
  • Jeon, Youkyung
  • Park, Se-Ho
  • Seo, Su-Kil
  • Jin, Dan
  • Choi, Inhak
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2012
Volume
56
Issue
5
Pages
1838–1848
Identifiers
DOI: 10.1002/hep.25906
PMID: 22711680
Source
Medline
License
Unknown

Abstract

Collectively, our results suggest that VSIG4(+) KCs play a critical role in the induction and maintenance of liver T- and NKT-cell tolerance, and that modulation of the VSIG4 pathway using a VSIG4.Ig fusion protein may provide useful immunological therapies against immune-mediated liver injury including autoimmune hepatitis.

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