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Protective effect of Rhus verniciflua Stokes extract in an experimental model of post-menopausal osteoporosis.

Authors
  • Jeong, Ji Heun1
  • An, Jong Hoon1
  • Yang, Hui2
  • Kim, Do-Kyung1
  • Lee, Nam-Seob1
  • Jeong, Young-Gil1
  • Na, Chun Soo3
  • Na, Dae Seung3
  • Dong, Mi-Sook4
  • Han, Seung Yun1, 5
  • 1 Department of Anatomy, Konyang University College of Medicine, Daejeon, Korea. , (North Korea)
  • 2 Department of Microbiology, Konyang University College of Medicine, Daejeon, Korea. , (North Korea)
  • 3 Lifetree Co., Ltd., Suwon, Korea. , (North Korea)
  • 4 School of Life Sciences & Biotechnology, Korea University, Seoul, Korea. , (North Korea)
  • 5 Myunggok Research Institute, Konyang University College of Medicine, Daejeon, Korea. , (North Korea)
Type
Published Article
Journal
Anatomy & cell biology
Publication Date
Sep 01, 2017
Volume
50
Issue
3
Pages
219–229
Identifiers
DOI: 10.5115/acb.2017.50.3.219
PMID: 29043101
Source
Medline
Keywords
License
Unknown

Abstract

Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor-binding affinities. In this study, the protective potential of RVS in PMO was evaluated by using an experimental animal model of PMO, which was established by ovariectomy (OVX) of female Sprague Dawley rats. The oral administration of RVS at 20 mg/kg or 100 mg/kg for 8 weeks markedly protected against OVX-induced atrophy of the uterine tube and reversed the elevation in the ratio of serum receptor activator of nuclear factor-κB ligand to osteoprotegerin, which is a marker of disease severity. In addition, RVS inhibited OVX-induced tibia bone loss, activated osteogenic activity, and suppressed osteoclastic activity in the tibial epiphyseal plate, a region of bone remodeling. Collectively, these factors indicated that the oral intake of RVS might be beneficial for the prevention of PMO.

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