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Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats

Authors
  • Patil, Ashwini S.1
  • Singh, Alok D.1
  • Mahajan, Umesh B.1
  • Patil, Chandragouda R.1
  • Ojha, Shreesh2
  • Goyal, Sameer N.1, 3
  • 1 R. C. Patel Institute of Pharmaceutical Education and Research, Department of Pharmacology, Dhule, Shirpur, Maharashtra, 425405, India , Shirpur (India)
  • 2 United Arab Emirates University, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Al Ain, Abu Dhabi, UAE , Al Ain, Abu Dhabi (United Arab Emirates)
  • 3 Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule, Maharashtra, 424001, India , Dhule (India)
Type
Published Article
Journal
Molecular and Cellular Biochemistry
Publisher
Springer-Verlag
Publication Date
Jan 16, 2019
Volume
456
Issue
1-2
Pages
105–113
Identifiers
DOI: 10.1007/s11010-019-03494-y
Source
Springer Nature
Keywords
License
Yellow

Abstract

We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue. Rats received either OPZ, LPZ (50 mg/kg/day, p.o.) individually for 7 days with concurrent administration of isoproterenol (ISO) (150 mg/kg, s.c.) on 6th and 7th day of study period to induce myocardial infarction. On the 8th day after measuring hemodynamic parameters, rats were killed and parameters were evaluated. ECG waves were found to be normal in the treatment group. ISO control rats revealed escalation in the oxidative stress as evidenced by depletion in the content of SOD, GSH, catalase and increase in the level of MDA and NO as compared with the normal rats. Treatment with OPZ and LPZ significantly reduced the ROS, indicated by an increase in the endogenous antioxidants and a decrease in NO and MDA levels. ISO control rats showed a significant elevation in the levels of pro-inflammatory cytokine TNF-α as compared to the normal and treatment group of rats. Administration of OPZ and LPZ does not exhibit any significant toxicity. Our findings reveal that multiple doses of OPZ and LPZ may have distinctly minimized the ISO-induced myocardial necrosis by declining the hmodynamic parameters, oxidative stress and pro-inflammatory cytokine TNF-α in myocardial infarcted rats.

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