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The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat.

Authors
  • Conde, C1, 2
  • Escribano, B M2, 3
  • Luque, E2, 4
  • Aguilar-Luque, M2, 5
  • Feijóo, M2, 5
  • Ochoa, J J1
  • LaTorre, M2, 5
  • Giraldo, A I2, 5
  • Lillo, R2, 6
  • Agüera, E1, 2
  • Santamaría, A7
  • Túnez, I2, 5, 8
  • 1 Neurology Service, Reina Sofia University Hospital, Cordoba, Spain. , (Spain)
  • 2 Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain. , (Spain)
  • 3 Department of Cell Biology, Physiology and Immunology, Faculty of Veterinary Medicine, University of Cordoba, Spain. , (Spain)
  • 4 Department of Morphological Sciences, Histology Section, Faculty of Medicine and Nursing, University of Cordoba, Spain. , (Spain)
  • 5 Department of Biochemistry and Molecular Biology, Faculty of Medicine and Nursing, University of Cordoba, Spain. , (Spain)
  • 6 Department of Socio-sanitary Sciences and Radiology and Physical Medicine, Psychiatry Section, Faculty of Medicine and Nursing, University of Cordoba, Spain. , (Spain)
  • 7 Neurology and Neurosurgery National Institute, Mexico City, Mexico. , (Mexico)
  • 8 Cooperative Research Thematic Network on Aging and Frailty (RETICEF).
Type
Published Article
Journal
Nutritional Neuroscience
Publisher
Maney Publishing
Publication Date
Jan 01, 2020
Volume
23
Issue
1
Pages
37–48
Identifiers
DOI: 10.1080/1028415X.2018.1469281
PMID: 29730972
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE).Dark Agouti 2-month old rats (25 males) were divided into five groups: (i) control group, (ii) EAE group, (iii) EAE+EVOO, (iv) EAE+HT, and (v) EAE+OA. At 65 days, the animals were sacrificed and the glutathione redox system and bacterial lipopolysaccharide (LPS) and LPS-binding protein (LBP) products of the microbiota in brain, spinal cord, and blood were evaluated.Gastric administration of EVOO, OA, and HT reduced the degree of lipid and protein oxidation, and increased glutathione peroxidase, making it a diet-based mechanism for enhancing protection against oxidative damage. In addition, it reduced the levels of LPS and LBP, which appeared as being increased in the EAE correlated with the oxidative stress produced by the disease.

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