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Protection of Lethally Irradiated Mice by Spleen Cells from Neonatally Thymectomized Mice

Authors
  • E. J. Yunis
  • R. A. Good
  • J. Smith
  • O. Stutman
Publication Date
Jun 01, 1974
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

Long-lived, immunologically vigorous (C3Hf × Af)F1 hybrids were produced after lethal irradiation by administration of spleen cells from C3Hf or syngeneic donors. Further, neonatally thymectomized C3Hf or Af strain donors reconstituted irradiated C3Hf or (C3Hf × Af)F1 hosts. In addition, C3Hf spleen cells from nonthymectomized 10- to 15-day-old donors protected irradiated hybrid mice, but Af cells of young mice as well as of older mice produced graft-versus-host reaction and early death in irradiated C3Hf or (C3Hf × Af)F1 hybrids.

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