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Protection of myocardial mitochondria against oxidative damage by selenium-containing abzyme m4G3.

Authors
  • Qi, D H
  • Luo, G M
  • Zhou, L
  • Yang, T S
Type
Published Article
Journal
Applied biochemistry and biotechnology
Publication Date
Dec 01, 1999
Volume
82
Issue
3
Pages
167–173
Identifiers
PMID: 10813024
Source
Medline
License
Unknown

Abstract

Selenium-containing abzyme (m4G3) was prepared and its protection of myocardial mitochondria against oxidative damage was studied using the swelling of mitochondria, quantity of lipid peroxidation products, and change in cytochrome-c oxidase activity as a measure of mitochondrial damage. The results showed that m4G3 could inhibit mitochondrial damage caused by the hypoxanthine-xanthine oxidase system in vitro. Electronic spin resonance (ESR) studies demonstrated that m4G3 could decrease the amount of free radicals generated in the damage system.

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