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Prostate cancer stem cell biology.

Authors
  • Yu, C
  • Yao, Z
  • Jiang, Y
  • Keller, E T
Type
Published Article
Journal
Minerva urologica e nefrologica = The Italian journal of urology and nephrology
Publication Date
Mar 01, 2012
Volume
64
Issue
1
Pages
19–33
Identifiers
PMID: 22402315
Source
Medline
License
Unknown

Abstract

The cancer stem cell (CSC) model provides insights into pathophysiology of cancers and their therapeutic response. The CSC model has been both controversial, yet provides a foundation to explore cancer biology. In this review, we provide an overview of CSC concepts, biology and potential therapeutic avenues. We then focus on prostate CSC including 1) their purported origin as either basal-derived or luminal-derived cells; 2) markers used for prostate CSC identification; 3) alterations of signaling pathways in prostate CSCs; 4) involvement of prostate CSCs in metastasis of PCa; and 5) microRNA-mediated regulation of prostate CSCs. Although definitive evidence for the identification and characterization of prostate CSCs still remains unclear, future directions pursuing therapeutic targets of CSCs may provide novel insights for the treatment of PCa.

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