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Prospects for vaccines for herpes simplex viruses.

Authors
Type
Published Article
Journal
Journal of the American Academy of Dermatology
Publisher
Elsevier
Volume
18
Issue
1 Pt 2
Pages
226–230
Source
UCSC Bioinformatics biomedical-ucsc
License
Unknown

Abstract

A subunit vaccine consisting of glycoprotein D from the surface of herpes simplex virus was prepared using recombinant deoxyribonucleic acid techniques to transfer the viral gene for glycoprotein D into Chinese hamster ovary cells. The glycoprotein D produced by these Chinese hamster cells combined with appropriate adjuvants effectively immunized mice and guinea pigs against herpes simplex infections. In addition to protecting guinea pigs from serious or fatal disease, the vaccine prevented a small group of guinea pigs from developing latent ganglionic infections. The vaccine has not yet been used in humans.

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